Riot Games has already released and distributed League of Legends in Latin America, Australia, the United States, Philippines, Singapore, Vietnam, Malaysia, Thailand, Canada, South Korea, Taiwan, China, Europe, Brazil, and Indonesia.[22] In China, Riot's primary shareholder Tencent Inc. distributes the game online. In Southeast Asia, online game service provider Garena publishes League of Legends. In North America, Riot Games self-publishes and operates the game and all of its customer service aspects.

In Europe, Riot Games originally signed an international licensing partnership with GOA, a division of Orange S.A.. On October 13, 2009, GOA and Riot announced that they would start channeling server access for players located in Europe, to GOA's dedicated servers. This restriction meant that players located in Europe would not be able to play on Riot's servers in the United States. Due to negative community feedback, the channeling decision was rescinded October 16, 2009. On May 10, 2010, Riot Games announced that they would take over distribution and operation of the game in Europe. To do so, Riot Games established a European headquarters in Dublin.[23]

On July 19, 2012, Riot Games launched the official Closed Beta Test servers for League of Legends Greece. The game has been fully localized, including translated menus, texts, subtitles, with all characters being dubbed. On April 16, 2013, Riot Games launched the official Open Beta Test servers for League of Legends Russia.